An analysis of 40 systemic lupus erythematosus patients with avascular necrosis of bone in Xinjiang area
LI Ju-feng
LUO Dong
DUO Lan?da li han
Abstract：Objective To investigate the risk factor of avascular necrosis (AVN) of bone in patients with systemic lupus erythematosus (SLE). Methods Total 40 SLE patients with AVN of bone in the First Afifliated Hospital of Xinjiang Medical University were enrolled in the presented study, and 58 SLE patients without AVN of bone were selected as the control group. Univariate analysis and multiple logistic regression analysis were applied with SPSS16.0 for associated impact factors. Results Univariate analysis revealed that there were signiifcant differences existed in the following variables between the two groups:discoid lesions, treat with azathioprine, the highest glucocorticoid does more than 50 mg prednisone, positive antibody to dsDNA, Anti-SSB antibody, serositis, lower platelet count. Multiple factor logistic regression analysis showed that the highest glucocorticoid does more than 50 mg prednisone was a high risk factor to AVN of bone, while treated with azathioprine was negatively correlated with AVN of bone. Conclusion Glucocorticoid treatment is a risk factor for the development of AVN of bone. The role azathioprine plays in the treatment of SLE need further research.
Keywords：LupuserythematosussystemicAvascular necrosis of boneGlucocorticoidAzathioprine
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 343-346 )