The clinical characteristics of hospital infection in patients with systemic lupus erythematosus and its inlfuenceing factors

doi:10.11786/sypfbxzz.1674-1293.20140505

Abstract：Objective To explore the clinical characteristics and inlfuenceing factors of hospital infection occurred in patients with systemic lupus erythematosus (SLE), so as to provide reference for prevention and control of the occurrence of hospital infection. Methods The information was collected by the methods of bedside investigation and hospital records review. According to whether accord with the hospital infection diagnosis standard issued in 2001 by the Ministry of health, total 295 SLE patients were divided into two groups:hospital infection group and the control group, then the hospital infection related factors were analyzed. Results Respiratory tract and skin mucous membrane infection were most common, the infection rate was 45.6%and 18.4%respectively. Bacterial infection was the most common type of infection (57.6%), gram-negative bacteria and gram-positive bacteria accounted for 38%and 19.6%respectively, including pseudomonas aeruginosa(13.0%), Bowman's acinetobacter(8.7%), E. coli(5.4%), Staphylococcus aureus(5.4%);followed by herpes virus infection (20.7%), and fungal infection (16.3%), in which white candida infection more than 8.7%. For the patients accepted glucocorticoid treatment, fungus infection rate was 40.0%, signiifcantly higher than the infection caused by herpes virus and TB (P<0.05);for the patients with hypoalbuminemia, the common bacterial infection rate was 63.3%, signiifcantly higher than that caused by fungi, herpes virus, and TB (P<0.05);for the patients with Leukopenia, TB infection rate was 9.1%, compared with the other groups, there was no statistically signiifcant difference (P>0.05). Length of patient stay in hospital, two or more organs damage, antibiotic used before infection, corticosteroids and immunosuppressant therapy, hypoalbuminemia and 24 h urine protein>3.5 g were the major risk factors that associated with nosocomial infection occurred in hospitalized SLE patients. Conclusions The respiratory tract and skin mucous membrane are the most common sites of infection, SLE patients’ nosocomial infection pathogens is given priority to gram-negative bacteria, followed by gram-positive bacteria. By shortening the length of hospital stay, effectively control of the condition, careful using of glucocorticoid and immunosuppressants, reasonable use of antibiotics and multiple organ damage prevention, etc, could reduce the occurrence of the hospital infection in SLE patients.