Renal damage and abnormal ifbrinolysis of nodular vasculitis:a retrospective analysis on 34 cases

JIANG Li-yuan; PU Xiong-ming

doi:10.11786/sypfbxzz.1674-1293.20140503

Abstract：Objective Through the analysis of the results of the clinical tests including serumβ2-micro-globulin (β2-MG), 24 hour urinary protein, plasma ifbrinogen(FG) and two D-dimer(DD), preliminarily assess the kidney damage and the anomalies of ifbrinolytic and coagulative system and their correlations in the hospitalized patients with vasculitis nodular. The results will provide assistance for the clinician to give an early intervention to the hospitalized patients with erysipelas who suffering from renal damage and the anomalies of ifbrinolytic and coagulative system. Methods Thirty four hospitalized patients with nodular vasculitis from May 2011 to September 2013 were collected and retrospectively analyzed. Laboratory data including serum β2-MG, 24 hour urinary protein, FG and DD of the patients were analyzed, so as to assess the patients’ renal damage and the anomalies of ifbrinolytic and coagulative system. Results Both serum β2-MG and 24 hour urinary protein value were increased in 11.76% of the patients; both FG and DD’ s values were increased in 29.41%of the patients;both Serumβ2-MG and FG were increased in 11.76%of the patients. The result of Pearson product-moment correlation analysis showed that there was a positive correlation between serum β2-MG and FG (variable linear correlation coefifcient r=0.7335, P<0.005). Conclusion A minority of the hospitalized patients with nodular vasculitis were complicated with renal damage and anomalies of ifbrinolytic and coagulative system. Renal damage and the anomalies of ifbrinolytic and coagulative system may affect each other, meanwhile as the risk factors to each other, there is a high positive correlation between the two factors.