Onychomadesis/Beau’s lines associated to hand-foot-mouth disease
Abstract：Objective To ifnd out the clinical features of nail dystrophy (e.g., Beau's lines and onychomadesis) and the correlations between onychomadesis/Beau’s lines and hand-foot-mouth disease (HFMD). Methods The data of HFMD patients and onychomadesis/Beau’s lines patients who had had HFMD before in our dermatology, paediatrics and infectious diseases department between March 2012 and March 2013 were analyzed. Results Two hundred and ninty ifve cases of HFMD were detected, female 157 cases, male 138 cases. All the cases resided in Shenzhen metropolitan area, and the mean age was 4.25 years old (range from 3 months to 28 years old). Fever and rash were the most common presenting symptoms. Lesions healed in 8.7 days (range from 7 to 14 days). CA16, EV71 and other enteroviruses (EVs) conifrmed as the viral pathogen. The nail dystrophy (e.g., Beau's lines and onychomadesis) was noted in 35 children within 4 to 6 weeks, and none of these children had a history of nail trauma, periungual dermatitis, periungual vesicular lesions, or a signiifcant medication intake history. For all the patients, the nail changes were temporary with a spontaneous normal regrowth in the subsequent 6 weeks. Conclusion The association of HFMD with Beau's lines and onychomadesis has not been reported previously in China. There was a strong association between HFMD and Beau’s line/onychomadesis. There are many evidences to support a correlation between HFMD and Beau’ s line/onychomadesis, and the mechanism of the nail matrix arrest is unclear. Onychomadesis and/or onycholysis is a newly recognized complication which will occur in the course of viral infections presenting clinically as HFMD, for its mild forms, this complication may be underestimated.
Keywords：Hand-foot-mouth diseaseBeau's line/onychomadesis
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 324-326,329 )