Clinical study of Xinhuang tablets combined with isotretinoin erythromycin gel in the treatment of acne vulgaris
Abstract：Objective To observe the efifcacy and safety of Xinhuang tablets combined with isotretinoin erythromycin gel in the treatment of acne vulgaris. Methods One hundred and iffty-ifve patients with mild to moderate acne vulgaris were randomly divided into the treatment group (n=80) and the control group (n=72). Both the two groups were topically treated with isotretinoin erythromycin gel once every night for 6 weeks, meanwhile the treatment group additionally given Xinhuang tablets, 3 tablets each time, 3 times/d. Followed up 6 weeks, clinical efifcacy and adverse reactions were evaluated at 2, 4, 6 weeks of the treatment. Results The effective rate of the treatment group and the control group were 21.51%and 14.29%respectively at 2 weeks of the treatment, and there was no statistical difference (P>0.05). The effective rates of the treatment group (54.43%, 84.81%) were signiifcant higher than those of the control group (30.00%, 54.29%) at 4 and 6 weeks of the treatment respectively (P<0.01). The main drug related adverse reaction was local irritation symptoms, and the incidence of the treatment group and the control group were 29.11%and 29.58%respectively, there was no statistically signiifcant difference between the two groups (P>0.05). Conclusion The treatment of Xinhuang tablets combined with isotretinoin erythromycin gel for acne vulgaris is effective, safe and with less adverse reactions.
Keywords：AcnevulgarisXinhuang tabletsIsotretinoinErythromycin
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 264-266 )