Correlation analysis of the degree of pain, serum CGRP and 5-HT concentration in patients with herpes zoster
Abstract：Objective To investigate the correlation among the degree of pain, serum calcitonin gene-related peptide (CGRP) and 5-hydroxytryptamine (5HT) concentration in patients with herpes zoster. Methods Forty hospitalized patients with herpes zoster were enrolled from April to July 2013, visual analogue scales (VAS) was adopted for pain score, CGRP and 5-HT in the patients’ peripheral blood were detected by ELISA, then the correlation between VAS scores and serum concentration of CGRP and 5-HT were analyzed by SAS software. Results CGRP concentration was negatively correlated with VAS scores, the correlation coefifcient was-0.763(P<0.01);5-HT had no correlation with the VAS scores, the correlation coefifcient was-0.171(P>0.05). Conclusion CGRP may play an important role in modulating pain of the patients with herpes zoster, the modulating role of 5-HT on pain of patients with herpes zoster may be more complex.
Keywords：Herpes zosterCalcitonin gene-related peptide5-HTPain
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 256-258 )