The relationship between Th17 cells related cytokines IL-17A, IL-17F, IL-21, IL-22 and psoriasis vulgaris
Abstract：ObjectiveTo investigate the relationship between Th17 cells related cytokines IL-17A, IL-17F, IL-21, IL-22 and psoriasis vulgaris.Methods Real-time RT-PCR was used to quantitatively detecte mRNA expressions of Th17-related cytokines IL-17A, IL-17F, IL-21 and IL-22 in PBMC of 30 patients and 20 normal humans, and in skin tissues of 12 cases of psoriasis vulgaris and 12 normal controls. Results The mRNA expressions of IL-17A, IL-17F, IL-21 and IL-22 were found signiifcantly higher in PBMC of patients compared with normal (P<0.05). Compared with normal controls, mRNA expressions of these four cytokines in psoriatic lesions increased (P<0.05). Conclusions The expression of Th17 related cytokines IL-17A, IL-17F, IL-21 and IL-22 mRNA increased signiifcantly in both PBMC and involved skin tissues of the psoriatic patients, which suggested that Th17 related cytokines might have some correlation with the pathogenesis of psoriasis vulgaris.
Keywords：Psoriasis vulgarisTh17 cellsInterleukins
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 190-192 )