The effect of imiquimod on Langerhans cells in the lesions of condyloma acuminatum
DING Xiao-jie
XIONG Xin-cai
WANG Ya-qin
Abstract：ObjectiveTo investigate the possible mechanism of imiquimod treatment on condyloma acuminatum(CA).MethodsThe samples were obtained from 30 cases at the same lesions before and after imiquimod application, 15 normal foreskin tissues were taken as controls. The expression of CD1a of these samples were analyzed by immunochemistry, positive cells were analyzed quantitatively by Motic colorful medical map analysis system.ResultsThirty samples were obtained before the treatment, while 24 samples were harvested at the end. Compared to the lesions of posttreatment and normal skin, the numbers of CD1a+LCs in the primary lesions were decreased obviously (P<0.05), but the lesions of posttreatment compared with normal skin, there was no signiifcant difference (P>0.05). Besides, the morphous of LC in the CA lesions was changed, typical LC was few. After the treatment of imiquimod, normal LC increased in the lesions. ConclusionsFunction recovery of LC in the lesions might be one of the mechanisms of imiquimod treating condyloma acuminatum.
Keywords：Condyloma acuminatumImiquimodLangerhans cell
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 182-184 )