A perspective on the association of skin diseases with iflaggrin
YANG Chao
CUI Yong
Abstract：Filaggrin is a kind of protein that interacts with keratins. It can bind to keratins 1 and 10 and other intermediate filament proteins to form tight bundles, which plays an important role in the function of the skin barrier. Some researchers found that loss-of-function mutations in the iflaggrin (FLG) gene are the cause of ichthyosis vulgaris and also the strong genetic predisposing factor for atopic dermatitis. Subsequent studies of the role of FLG-null mutations have identiifed a series of signiifcant related to atopic disease phenotypes. However, many questions still remain to be answered about the precise mechanisms between the protein and the skin barrier. This review aims to sum up some important information on iflaggrin research over the past few years.
Keywords：FilaggrinProiflagginLoss-of-function mutationsSkin diseases
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 115-118 )