The expressions of COX-2 and Ki67 in Bowen's disease
Abstract：Objective To study the expressions and relationship of COX-2 and Ki67 in Bowen’s disease. Methods Specimens from 27 Bowen's disease patients and 15 normal persons were assayed for COX-2 and Ki67 by immunohistochemistry. Results The expressions of COX-2 and Ki67 in normal skin was very low, but in Bowen's disease was signiifcantly increased. COX-2 was positive correlated with Ki67 in Bowen's disease(r=0.451, P<0.05). Conclusion The abnormal level of COX-2 and Ki67 plays a role in carcinogenesis and development of Bowen's disease, the over-expression of COX-2 may result in the proliferation of tumor cell.
Keywords：Bowen's diseaseCyclooxygenase-2Ki67
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 107-109 )