The detection of human papillomavirus in patients with condyloma acuminatum
XIAO Zi-e
HUANG Jie
Abstract：Objective To use lfuorescent quantitative polymerase chain reaction (FQ-PCR)for detection of human papillomavirus(HPV) DNA and HPV typing in patients with condyloma acuminatum (CA). Methods FQ-PCR for HPV typing and detection of HPV-DNA in wart tissue were performed in 278 patients with CA. Results In the 278 cases, 173 cases were cured after carbon dioxide laser treatment, but 105 cases have a relapse. HPV subtype analysis was performed. The samples of 278 cases detected were all HPV-DNA positive (100.00%), including 244 cases(87.77%) with genotype HPV6/11, 7 cases(2.52%)with genotype HPV16/18 and 27 cases(9.71%)with genotype HPV6/11and HPV 16/18. 278 HPV-DNA positive patients without being treated in groups were compared according to the HPV-DNA virus load. There were 23 recurrence cases in 106 cases with virus load 103~105 copies/ml.There were 29 recurrence cases in 82 cases with virus load 105~107 copies/ml. There were 53 recurrence cases in 90 cases with virus load>107 copies/ml. 79 recurrence cases with HPV6/11, 5 recurrence cases with HPV16/18 and 21 recurrence cases with HPV6/11 and HPV16/18 were observed. Conclusion Detecting HPV-DNA can distinguish the high-risk HPV from low-risk HPV infection, and it can predict the possibility of condyloma recurrence.
Keywords：Condyloma acuminatumHuman papillomavirusPolymerase chain reactionFluorescent quantitation
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 99-101 )