The clinical observation of oral isotretinoin with CO2-laser or ALA-PDT in the treatment of condyloma accuminatum
WANG Han-ying
YANG Xiu-min
Abstract：Objective To observe therapeutic effect and recurrence rate of oral isotretinoin with CO2-laser or ALA-PDT therapy in the treatment of condyloma accuminatum. Methods Totally 120 cases of condyloma accuminatum patients diagnosed in outpatient were randomly divided into 4 groups. Group A:30 cases, only ALA-PDT treatment. Group B:30 cases, ALA-PDT treatment with oral isotretinoin 10 mg, 3 times a day, and turning to 10 mg per day till the lesion disappearing clearly, stopping after 1 month. Group C:30 cases, only CO2-laser treatment. Group D:30 cases, CO2-laser treatment with oral isotretinoin, same to Group B. All groups have observation the other week, recorded lesion condition and adverse effect. Physical therapy until the lesion disapearing clearly. Follow up 6 months. Results Group A:19 cases heal, 9 cases excellence, 2 cases inefifcacy. Group B:26 cases heal, 3 cases excellence, 1 cases inefifcacy. Group C:10 cases heal, 13 cases excellence, 7 cases inefifcacy. Group D:15 cases heal, 11 cases excellence, 4 cases inefifcacy. There was signiifcant difference between Group AB and group CD in therapeutic effect, respectively (AB:χ2=6.788, P<0.05;CD:χ2=6.652, P<0.05). Recurrence rate:Group A:21.1%;Group B:11.5%;Group C:60.0%;Group D:40.0%. There was signiifcant difference between GroupAB and group CD in recurrence rate (AB:χ2=0.756, P<0.05;CD:χ2=0.962, P<0.05). Conclusion Oral Isotretinoin with CO2-laser or ALA-PDT has great therapeutic effect and low recurrence rate.
Keywords：Condyloma accuminatumIsotretinoinALA-PDTLaserCO2Therapeutic effectRecurrence
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 89-91 )