Study on the effect of human-like collagen dressing on facial seborrheic dermatitis and skin barrier function
Abstract：Objective To investigate the effect and safety of human-like collagen dressing (HLCD) on facial seborrheic dermatitis and the effect of HLCD on skin barrier function. Methods 67 female outpatients with facial seborrheic dermatitis were randomly classiifed into two groups to be treated with HLCD combined with topical ketoconazole cream (experiment group, n=34) or ketoconazole cream alone (control group, n=33) for ten days. Results Compared with control group, experiment group had significantly lower symptom score and TEWL and higher stratum corneum hydration after ten days treatment (1.06±1.06 vs. 1.94±1.17, 11.99±5.84 vs. 16.17±8.47, 40.20±11.69 vs. 34.13±10.86, t=-3.198,-2.306, 2.185, P=0.002, 0.024, 0.033). No obvious adverse effect was found. Conclusions HLCD could alleviate skin lesion and improve skin barrier function in the treatment of facial seborrheic dermatitis, it could be a good choice for combination therapy of facial seborrheic dermatitis.
Keywords：DermatitisseborrheicHuman-like collagenSkin barrier
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 25-27 )