Efifcacy and safety of total glucosides of paeon capsule combined with acitretin and narrow band ultraviolet B(NB-UVB) irradiation in the treatment of moderate to severe psoriasis vulgaris
Abstract：Objective To observe the efifcacy and safety of total glucosides of paeon capsule combined with acitretin and narrow band ultraviolet B(NB-UVB) irradiation for the treatment of moderate to severe psoriasis vulgaris. Methods Sixty cases of moderate to severe psoriasis vulgaris were equally randomized into two groups and treated for 8 weeks. The treatment group was treated with total glucosides of paeon 600 mg, 3 times a day orally, combined with acitretin 0.5 mg/(kg.d) and NB-UVB irradiation(every other day), the control group was treated with acitretin 0.5 mg/(kg.d) and NB-UVB irradiation(every other day). The adverse reaction and the efifcacy of treatment was evaluated by psoriasis area and severity index(PASI) scores. Results 28 cases of treatment group and 27 cases of control group completed treatment. The PASI scores in the treatment group(4.23±2.96) were signiifcantly lower than that of control group(7.45±3.05) (P<0.05 ). The efifcacy rates in the treatment group(89.28%) were signiifcantly higher than that of control group(66.67%) (P<0.05). No serious adverse reaction occurred in both two groups. Conclusion Glucosides of paeon capsule combined with acitretin and NB-UVB irradiation showed good efifcacy and safety for moderate to severe psoriasis vulgaris patients, it is worthy of clinical popularization and application.
Keywords：PsoriasisvulgarisTotal glucosides of paeonAeitretinUltraviolet Bnarrow band
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 19-21,24 )