The expression of Caspase-3 and bcl-2 in psoriasis lesions before and after calcipotriol treatment
LIU Jian
HU Cheng
CHEN Yi-lei
Abstract：Objective To explore the expression of Caspase-3 and bcl-2 before and after calcipotriol treatment of psoriasis and their signiifcance. Methods Immunohistochemical method was adopted to detect the expression of Caspase-3 and bcl-2 in the lesional and non-lesional skin in 12 cases of psoriasis patients before and after the treatment of calcipotriol. Results The expression of bcl-2 in psoriatic keratinocytes signiifcantly increased after calcipotriol treatment (P<0.05), meanwhile the expression of Caspase-3 showed no signiifcant difference (P>0.05). Conclusion Promoting bcl-2 induced keratinocyte apoptosis may be one of the mechanisms of calcipotriol treating psoriasis.
Keywords：PsoriasisCalcipotriolCaspase-3Bcl-2
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 328-330 )