The correlation between bone metabolism and PASI of progressive psoriasis vulgaris

doi:10.11786/sypfbxzz.1674-1293.20130602

Abstract：Objective To investigate the correlation between PASI scores of progressive psoriasis vulgaris and the bone metabolism markers:TRACP-5b, serum calcium, BAP and ALP. Methods Eighty-eight patients with progressive psoriasis vulgairs were assessed by PASI scoring system, then divided into three groups according to the score:group A (the score ≤ 10), group B (the score between 10 and 20), and group C (the score ≥ 20). The bone density of the patients’ lumbar, femoral neck and left forearm were detected by dual energy x-ray absorptiometry respectively, the concentration of serum ALP and calcium were detected under the same condition, and the concentration of serum TRACP-5b and BAP were detected by ELSIA. Results For the concentration of bone formation markers ALP and bone resorption indicator TRACP-5b and blood calcium, there was signiifcant difference between group A and C (P<0.05);for the concentration of the osteoblast markers BAP, there was no signiifcant difference between the every two groups (P>0.05);for Lumbar spine BMD, there was signiifcant difference between the group C and the other two groups (P<0.05);for femoral neck BMD, there was signiifcant difference between the group A and the other two groups(P<0.05);for the left forearm BMD, there was no signiifcant difference between the every two groups (P<0.05);for the peak of the bone mass (T-value) of lumbar spine and femoral neck, there was signiifcant difference between group C and the other two groups (P<0.05), for the T-value of left forearm, there was no signiifcant difference (P>0.05) between the every two groups. Conclusion Abnormal bone metabolism and bone loss may occur in the patients with progressive psoriasis vulgaris, and the severity is proportional to the PASI score.