The efifcacy and compliance of tacrolimus ointment for the children with mild to moderate atopic dermatitis
ZHOU Dong-ji
HU Yi-qiang
YU Jian-feng
Abstract：Objective To evaluate the efficacy, safety and compliance of tacrolimus ointment 0.03% for the children with mild to moderate atopic dermatitis. Methods In this 3-week, randomized, double-blind, placebo-controlled, parallel-group trial, sixty cases of children with atopic dermatitis were randomized 1:1 to receive treatment with topical 0.03%tacrolimus ointment or vaseline cream combined with fusidic acid ointment. Follow-up observations of the patients were carried out weekly, efifcacy was evaluated by the SCORAD index. Results Itching and symptom score in the experimental group declined more signiifcantly than that in the control group (P<0.05). The time to symptoms alleviation and clinical cure time for the experimental group were signiifcantly shorter than the control group (P<0.05). The effective rate of the experimental group and the control group were 93.3%and 69.5%, and the compliance rate of the experimental group and the control group were 100%and 76.7%respectively, there were signiifcant differences between the two groups (P<0.05). Conclusion Tacrolimus ointment 0.03%was effective in the treatment of children with mild to moderate atopic dermatitis, which with better safety and good compliance.
Keywords：DermatitisatopicTacrolimusChildren
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 207-209 )