The changes of hair follicle stem cells in alopecia caused by discoid lupus erythematosus and alopecia areata and their signiifcance
GUAN Hai-hong
LI Hong-xin
LIN lin
Abstract：Objective To investigate the changes of hair follicle stem cells and their signiifcance in the common scaring alopecia and non-scaring alopecia caused by discoid lupus erythematosus (DLE) and alopecia areata (AA). Methods Immunohistochemical method was performed to detect CK15 (cytokeratin 15) and CD200, two markers of hair follicle stem cells, in the alopecia lesions of 16 patients with DLE(8 cases) or AA(8 cases). Samples from healthy people after plastic surgery were as the controls. Results The positive expression of CK15 and CD200 in the follicles of DLE lesions was 37.5%and 12.5%respectively, signiifcantly diminished compared with that in healthy controls (both are 100%, P<0.05). The positive expression of CK15 in follicles of AA lesions was normal, while the positive expression of CD200 was 50%, signiifcantly diminished compared with that in healthy controls (P<0.05). Conclusion Hair follicle stem cells were signiifcantly damaged in scarring alopecia caused by DLE but not AA, meanwhile the expression of CD200 decreased in follicles of patients with AA. The damage of hair follicle stem cells may be associated with the irreversible loss of hair follicles in DLE, and the low expression of CD200 may be associated with the pathogenesis of DLE and AA.
Keywords：Lupus erythematosusdiscoidAlopeciaFollicleStem cell
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 204-206,209 )