The diagnostic value of anti-dsDNA antibody, anti-nucleosome antibody and anti-C1q antibody for systemic lupus erythematosus
LU Qing-li
SHAN Xin-jie
MENG Xin-yan
Abstract：Objective To investigate the diagnostic signiifcance of anti-dsDNA antibody, anti-nucleosome antibody(AnuA) and anti-C1q antibody for systemic lupus erythematosus (SLE). Methods anti-dsDNA antibody, AnuA and anti-C1q antibody were detected in serum samples including 111 from SLE, 54 from non-SLE diseases and 43 from healthy blood donors. Then the sensitivity and speciifcity of these parameters for SLE diagnosis were studied. Results Both the positive rate and average concentration of AnuA and the positive rate of anti-C1q antibody in SLE were higher than that in non-SLE diseases or in healthy controls (P<0.05). The most sensitive and speciifc parameter for SLE diagnosis was AnuA (52.3%) and anti-dsDNA antibody (97.9%) respectively. For the comboes of any two antibodies, the sensitivity and speciifcity of anti-dsDNA antibody combined with AnuA were highest (29.7%and 99.0%respectively). As to the distribution of the three antibodies in the studied groups, the coincidence rate of anti-dsDNA antibody and AnuA was 81.25%, and the value of Kappa was 0.515. Conclusion In serial tests, combined detection of the three antibodies enhanced the speciifcity of SLE diagnosis but the sensitivity was weakened. Whether the concentration levels of anti-C1q antibody and AnuA may be used as valuable referenced parameters for the diagnosis of SLE as well as the relationship between the antibodies and the disease progression need further research to clarify.
Keywords：Lupus erythematosussystemicAnti-dsDNA antibodyAnti-nucleosome antibodyAnti-C1q antibody
Publication Date：2013-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 201-203 )