Clinical application of laser-assisted drug delivery in the treatment of hypertrophic scars
LIU Zonghui
XIE Shengnan
LI Yanan
ZHU Lin
TAO Yu
Abstract：Objective To explore the clinical effect of fractional carbon dioxide laser-assisted betamethasone delivery in the treatment of hypertrophic scars.Methods Data from consecutive patients with hypertrophic scars treated between January 2024 and Jan-uary 2025 were collected and divided 190 patients into groups based on different treatment methods.The observation group received frac-tional CO2 laser treatment followed immediately by topical application of betamethasone injection and ointment to seal the wounds,while the control group received local injection of compound betamethasone injection.Treatments were administered once a month,with four sessions constituting one course.Follow-up was conducted six months after the final treatment.Evaluations were performed using the Vancouver scar scale(VSS),the visual analog scale(VAS)for pain,and by recording the occurrence of complications.Results Hypertrophic scars in both groups showed significant improvement.However,the observation group demonstrated a lower VSS score compared to the control group(P＜0.05),indicating better scar treatment outcomes.The observation group also reported a lower VAS score(P＜0.05),reflecting less pain.Furthermore,the incidence of complications was lower in the observation group(9.1%and 28.8%).Conclusion Fractional car-bon dioxide laser-assisted betamethasone delivery is a safe,effective and valuable strategy for treating hyperplastic scar.
Keywords：Fractional laserSteroidHyperplastic scarDeliveryEffect
Publication Date：2026-02-15
Online Publishing Date：2026-03-31(First online date of this platform, not the publication date of the document)
Pages：4( 124-127 )