Clinical study on fractional microneedle radiofrequency combined with hyaluronic acid micro-filling in the treatment of atrophic acne scars

ZHAO Demei; JIANG Yanan; JIANG Yerong; GAO Yu; MA Liwen; LI Shan; YAN Lu; YAN Xin; TAN Qian

doi:10.3969/j.issn.1673-7040.2026.02.002

Abstract：Objective To explore the clinical efficacy and safety of fractional microneedle radiofrequency(FMR)combined with hyaluronic acid(HA)micro-filling in the treatment of facial atrophic acne scars(AAS).Methods A retrospective analysis was conducted on the clinical data from 65 patients with facial AAS treated in our department from January 2022 to July 2024.According to different treatments,the patients were divided into control group(treated with FMR alone,n=33)and combination group(treated with FMR+HA filling,n=32).Treatments were administered every 3 months for 3 cycles,with 3-month follow-up post-treatment.Both groups were eval-uated before and after treatment for clinical efficacy,ECCA score,VISIA skin physiological indicators,VAS pain score,patient satisfaction and adverse reactions.Results The total effective rate in the combination group(93.75%)was significantly higher than that in the control group(75.76%),P<0.05.There was no statistically significant difference in ECCA scores between the two groups before treatment(P>0.05);af-ter treatment,the ECCA scores were markedly decreased in both groups,and the decrease in the combination group was lower than that in the control group,with a statistically significant difference(P<0.05).Among the VISIA skin physiological indicators,there were no statistically significant differences in the eight indicators between the two groups before treatment(P>0.05);after treatment,compared with the control group,the combination group had significantly lower scores in the five indicators including spots,texture,pores,porphyrin and inflamma-tion(P<0.05),while no significant differences were observed in wrinkles,ultraviolet spots and brown spots(P>0.05).There was no statisti-cally significant difference in VAS pain scores between the two groups(P>0.05).The main adverse reactions were erythema and edema,the incidence of which in the combination group(15.63%)was lower than that in the control group(36.36%),P<0.05,and the healing time of the combination group was shorter than that of the control group(P<0.05).The patient satisfaction of the combination group(93.75%)was higher than that of the control group(72.73%),P<0.05.Conclusion FMR combined with HA micro-filling can significantly improve the depression and skin texture of AAS,with good safety and high patient satisfaction,which is worthy of clinical promotion and application.