The research progress on the stability of ectopic transplanted tissue-engineered cartilage derived from mesenchymal stem cells
GUO Fan
PAN Bo
Abstract：Cartilage tissue engineering technology provides a novel solution for the reconstruction of superficial organs,featuring precise repair,low donor-related injury,and long-term regenerative effects.The improvement of tissue-engineered cartilage technology has always been a central focus in the field in recent years,with significant progress achieved.However,the clinical translation of tissue-engi-neered cartilage induced by mesenchymal stem cells as seed cells still faces challenges.Specifically,the cartilage phenotype exhibits insta-bility after ectopic transplantation,manifested as chondrocyte hypertrophy,matrix mineralization,and cartilage ossification.The authors sum-marized the current potential mechanisms underlying ectopic cartilage ossification,classified and organized the methods for delaying ossifica-tion based on existing technical approaches,reviewed the strategies for enhancing its stability,and provided an outlook on future research.
Keywords：Mesenchymal stem cellsTissue engineeringEctopic transplantVascularizationPhenotypic stability
Publication Date：2025-12-15
Online Publishing Date：2026-01-19(First online date of this platform, not the publication date of the document)
Pages：7( 749-754,后插1 )