The effect of chitosan quaternary ammonium salt biocolloid on promoting wound healing in facial plastic surgery
DONG Dong
CHEN Liang
JI Lina
ZHU Jingjing
WANG Heng
ZHOU Yiqun
GUO Yu
ZHANG Wenqun
LIU Tianyi
BI Bo
Abstract：Objective To investigate the efficacy of chitosan quaternary ammonium salt bio-colloidal fluid in promoting the heal-ing of incisions after facial plastic surgery.Methods From July 2022 to July 2023,recruiting patients with postoperative wounds were randomly assigned to either an experimental or a control group.Employing a prospective double-blind randomized controlled study design,the control group underwent standardized closure of plastic surgery incisions with regular dressing changes.The experimental group re-ceived chitosan quaternary ammonium salt bio-colloidal spray on the day of surgery,postoperative days 1,4,and 7(suture removal day),with follow-up photography.A 6 months postoperative follow-up assessed incision healing using the visual analog scale(VAS)and evaluat-ed scarring using the modified vancouver scar scale(mVSS).Results Fifty patients with postoperative wounds from facial plastic surgery,25 in each group,were included.Throughout the follow-up,neither group exhibited significant adverse reactions such as allergies or infections.The experimental group demonstrated significantly lower mVSS total scores and scores for scar pigmentation and pliability compared to the control group.Additionally,patient satisfaction with incision healing in the experimental group was notably higher than in the control group.Conclusion In summary,chitosan quaternary ammonium salt bio-colloidal fluid effectively enhances incision healing in facial plastic surgery.It holds clinical application and promotional value by inhibiting scar proliferation.
Keywords：ScarsQuaternary ammonium salt of chitosanWound healingFacial cosmetic surgery
Publication Date：2025-12-15
Online Publishing Date：2026-01-19(First online date of this platform, not the publication date of the document)
Pages：4( 722-725 )