Research progress of TGF-β1 and TGF-β3 in pathological scars
TAN Shenxing
LIU Yuanyuan
LIU Xuankai
QIAO Youlu
NIU Changying
Abstract：The formation of scars,accompanied by continuous changes in normal tissue structure,is the result of wound healing and fibrotic disorders.When the skin is damaged,fibroblasts proliferate and secrete collagen fibers to promote wound healing.However,if this proliferation and secretion are out of control,it will lead to the formation of abnormal scars,manifested as disordered arrangement of collagen fibers and dermal fibrosis,and then cause excessive fiber hyperplasia.Transforming growth factor-β(TGF-β)is a multi-direc-tional differentiation,proliferation,migration and immune regulatory factor.It can transform the phenotype of normal fibroblasts and is in-volved in the Extracellular matrix at the same time.The secretion and differentiation of ECM and other physiological processes have exten-sive biological significance.This article mainly focuses on the two special isomers,TGF-β1 and TGF-β3,elaborating on their expression at different development stages of pathological scars,as well as the possible feedback regulatory mechanisms between the two isomers.It pro-vides a review to offer experimental basis and research ideas for the further clinical application of TGF-β factors in the treatment of patho-logical scars.
Keywords：Transforming growth factor-βPathological scarsTreatment
Publication Date：2025-11-15
Online Publishing Date：2025-12-22(First online date of this platform, not the publication date of the document)
Pages：5( 693-696,后插4 )