The efficacy and safety of autologous skin transplantation combined with vacuum sealing drainage and autologous platelet-rich plasma gel in treating refractory diabetic foot ulcer
HU Zongrui
PAN Yayun
LI hao
CHEN Congbai
Abstract：Objective To analyze the efficacy and safety of autologous skin transplantation combined with vacuum sealing drainage(VSD)and autologous platelet-rich plasma(PRP)gel in treating refractory diabetic foot ulcer.Methods The study subjects included 78 patients with refractory diabetic foot ulcer received by Department of Plastic Surgery,Tianmen First People's Hospital from June 2023 to November 2024.According to the random number table,they were assigned into the regular group(VSD+PRP gel)and the combined group(VSD+PRP gel+autologous skin transplantation).The wound healing,pain degree,safety,efficacy,diabetes foot ulcer healing scale(DMIST)score,and the changes in vascular growth factor and inflammatory factors were compared between before and after treatment.Results After treatment 1 month,the matrix metalloproteinase-9(MMP-9),tumor necrosis factor-α(TNF-α),procalcitonin(PCT),monocyte chemoattractant protein-1(MCP-1),numerical rating scale score(NRS)and DMIST score in both groups decreased(P＜0.05),and with the combined group being lower than the regular group(P＜0.05);the platelet-derived growth factor(PDGF)and basic fibroblast growth factor(bFGF)increased in both groups(P＜0.05),and with the combined group being higher than the regular group(P＜0.05).The combined group had shorter wound healing time than the regular group(P＜0.05).The combined group showed prominently higher efficacy(89.74％)than the regular group(69.23％)(P＜0.05),but there was no prominent difference in the incidence of untoward reactions(P＞0.05).Conclusion Autologous skin transplantation combined with VSD and PRP gel can accelerate the process of wound healing in patients with refractory diabetic foot ulcer,and it is effective and safe.
Keywords：Autologous skin transplantationVacuum sealing drainageAutologous platelet-rich plasma gelDiabetic foot ulcer
Publication Date：2025-11-15
Online Publishing Date：2025-12-22(First online date of this platform, not the publication date of the document)
Pages：5( 641-645 )