Effect of PRP and rhGM-CSF gel on chronic refractory wounds and changes of wound growth factor levels
CHEN Jian
OU Hanjie
LI Minghua
LONG Jun
YE Cong
HE Zhiwei
Abstract：Objective To observe the effect of autologous platelet rich plasma(PRP)and recombinant human granulocyte macrophage colony stimulating factor(rhGM-CSF)gel on chronic refractory wounds and the changes of wound growth factor levels.Methods From January 2023 to July 2024,112 patients with chronic refractory wounds were selected,including 56 patients with rhGM CSF gel(control group)and 56 patients with PRP gel(observation group).The treatment effect,clinical related indicators,inflamma-tory factors[white blood cell count(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)]levels,wound growth factors[PDGF,VEGF,epidermal growth factor(EGF)]levels and adverse reactions were compared between the two groups.Results Com-pared with the control group,the observation group had better overall effective rate,wound healing,hospitalization time,VAS score at 7 and 14 days of treatment,and bacterial conversion rate(all P＜0.05).After treatment,the levels of WBC,CRP,and ESR decreased in both groups,and the observation group was lower than the control group;The levels of PDGF,EGF,and VEGF all increased,and the observation group was higher than the control group(all P＜0.05).The overall incidence of adverse reactions was comparable between the two groups(P＞0.05).Conclusion Compared with rhGM-CSF gel,PRP gel has better effect in the treatment of chronic refractory wounds,which can quickly promote wound healing,relieve pain and improve the level of wound growth factor.
Keywords：Autologous platelet rich plasmaRecombinant human granulocyte macrophage colony stimulating factorChronic re-fractory woundsGrowth factorCurative effect
Publication Date：2025-10-15
Online Publishing Date：2025-11-25(First online date of this platform, not the publication date of the document)
Pages：4( 628-631 )