Effect of recombinant human type Ⅲ collagen combined with ultrapulse CO2 fractional laser on repairing facial atrophic scars and its impact on TGF-β1,VEGF,and aesthetic appearance
YANG Weiqi
LI Qiongfen
XU Lujuan
WANG Jihua
Abstract：Objective To investigate the effect of recombinant human type Ⅲ collagen(Rhc-Ⅲ)combined with Ultra-pulsed CO2 fractional laser on repairing facial atrophic scars and its impact on transforming growth factor-β1(TGF-β1),vascular endothelial growth factor(VEGF),and aesthetic appearance.Methods One hundred and forty-six patients with facial atrophic scarring were selected from May 2022 to January 2024 and divided into two groups of 73 cases each according to the randomized numerical table method.The control group underwent hyperpulsed CO2 fractional laser,based on which the study group was treated with Rhc-Ⅲ gel after laser.The two groups were compared in terms of treatment effect,scar weighting score(ECCA),Vancouver scar scale(VSS),skin testing system(VISIA),skin parameters(erythema index,skin texture value,spot value),TGF-β1,VEGF expression in the scabbed tissues,aesthetic appearance in the two groups after treatment,and statistics of adverse reactions during the treatment period.Results The total effective rate of the study group(95.89％)was higher than that of the control group(80.82％)(P＜0.05);the ECCA,VSS score,erythema index,skin texture val-ue,and blotchy value of the study group were lower than that of the control group at 3 months after treatment(P＜0.05),the expression levels of TGF-β 1 and VEGF in the scabbed tissues of the study group at the first,second,and third treatment sessions were higher than those in the control group(P＜0.05);the aesthetic appearance of the study group was superior to that of the control group(P＜0.05),the incidence of adverse reactions was lower in the study group(8.22％)than in the control group(20.55％)(P＜0.05).Conclusion The combination of Rhc-Ⅲ and Ultra-pulsed CO2 fractional laser has a good effect on repairing facial atrophic scars,reducing erythema and pigmentation,im-proving skin texture,and enhancing facial aesthetics.
Keywords：Atrophic scarUltra-pulsed CO2 laserRecombinant human type Ⅲ collagenTransforming growth factor-β1Vas-cular endothelial growth factor
Publication Date：2025-10-15
Online Publishing Date：2025-11-25(First online date of this platform, not the publication date of the document)
Pages：5( 602-605,后插8 )