Clinical efficacy of extracorporeal arterial mechanical perfusion of alprostadil in reconstructing microcirculation of ischemic limbs to promote wound healing
DOU Guoqi
GAO Lei
QIN Xinyuan
JI Qinghui
WANG Jiangning
Abstract：Objective To evaluate the clinical efficacy of extracorporeal arterial mechanical perfusion in local drug delivery for reconstructing microcirculation in ischemic limbs to promote wound healing.Methods A retrospective study was conducted on 58 pa-tients with chronic limb-threatening ischemic wounds from January to December 2024.The patients were divided into two groups based on treatment.The patients in observation group received extracorporeal arterial mechanical perfusion of alprostadil(6 h/d for 7 d)with daily wound dressing changes.The patients in control group received continuous intravenous alprostadil infusion(once daily for 7 d)with daily wound dressing changes.Transcutaneous oxygen pressure(TcPO2),skin temperature,and wound area were compared between groups post-treatment.Results The TcPO2 and skin temperature of the affected limbs in both groups were significantly increased compared with those before treatment,and the wound area was smaller than that before treatment(P＜0.05).The observation group exhibited greater im-provements in TcPO2,skin temperature,and wound healing(P＜0.05).Conclusion Extracorporeal arterial mechanical perfusion of al-prostadil can accelerate wound healing by restoring microcirculation in ischemic limbs.
Keywords：External mechanical perfusionMicrocirculationAlprostadilLocal drug deliveryWound healing
Publication Date：2025-09-15
Online Publishing Date：2025-10-29(First online date of this platform, not the publication date of the document)
Pages：5( 548-552 )