Animal experiments on the therapeutic effect of a novel skin closure device with continuous tension
LI Zimu
GUO Bingyu
FU Zhiqiang
ZHANG Tinghui
LIU Ruidi
LI Xinqi
WANG Qixin
XIE Bing
Abstract：Objective To discuss the therapeutic effect of a new skin tension closure device on wound reduction and wound clo-sure.Methods Small Bama pigs were selected for the experiment,and two groups of fusiform wounds were made on both sides of each animal's back.The skin tension control closure device and the control product disposable skin co-attachment device were respectively ap-plied to the skin wounds.The control group was treated with the control product disposable skin pulling device.The wound closure time and wound healing after secondary suture were observed and recorded.The risk of scar formation after wound removal and healing was as-sessed by the Vancouver Scar Assessment Scale.The animal tissues cut at different time points were observed by hematoxylin eosin(HE)staining and Masson staining.The wound data of the experimental group and the control group were statistically compared and analyzed.Results The wound healing rate of the experimental group was higher than that of the control group on the same day.Compared with the control group,the experimental group had more obvious effect of immediate wound tightening,and the average daily wound healing rate of the experimental group was higher than that of the control group.There was a significant difference in the early wound healing rate between the experimental group and the control group.The wound healing rate of the experimental group was faster than that of the control group.The wound healing rate of the experimental group was(90.36±2.60)％and(93.28±2.97)％on the postoperative day and the first postoperative day,respectively,and that of the control group was(74.21±3.58)％and(85.26±6.33)％,respectively.The difference was statistically signifi-cant(P＜0.05).The wound healing rate was(90.36±2.60)％in the experimental group and(74.21±3.58)％in the control group on the day af-ter surgery.During the healing period,both the experimental group and the control group achieved lower scores when the wound was com-pletely closed,and the wound healed well.Both the experimental group and the control group achieved Grade A wound healing with good wound healing and slight skin scar formation inclination.The results of HE and Masson staining were similar between the experimental group and the control group,the scar formation risk was at a low level.Conclusion The pig wound closure experiment confirmed that the new skin tension clamper for the treatment of skin and soft tissue defect wound has definite curative effect,short wound healing time,few complications,simple operation and safe use.
Keywords：Wound healingSkin clamperScar formation inclination
Publication Date：2025-08-15
Online Publishing Date：2025-09-08(First online date of this platform, not the publication date of the document)
Pages：6( 468-473 )