Comparative study on the efficacy of nucleus pulposus dissection combined with bleomycin and compound betamethasone in-jection in the treatment of auricular scar tissue

LIU Haihong; LIANG Jiulong

doi:10.3969/j.issn.1673-7040.2025.07.010

Abstract：Objective To investigate the efficacy of nucleus pulposus dissection combined with bleomycin and compound be-tamethasone injection in the treatment of auricular scar tissue,and to compare the effects on the expression of transforming growth factor beta 1(TGF-β1)and epidermal growth factor(EGF).Methods From March to July 2025,80 patients with ear scar tissue treated in De-partment of Burn and Plastic Surgery,General Hospital of Northern Theater Command were selected and randomly divided into three groups:A(n=20),B(n=30),and C(n=30).Group A patients received nucleus pulposus dissection treatment,group B patients received nu-cleus pulposus dissection combined with compound betamethasone injection treatment,and group C patients received nucleus pulposus dissection combined with bleomycin injection treatment.Compare the levels of TGF-β1,EGF,Vancouver Scar Scale(VSS)score,12 Item Pruritus Severity Scale(12-PSS)score,and incidence of adverse reactions among the three groups.Results Before surgery,there was no statistically significant difference(P＞0.05)in the levels of TGF-β1,EGF,VSS score,and 12-PSS score between Group A and Group C,as well as between Group C and Group B.At 12 and 16 weeks postoperatively,the levels of TGF-β1,EGF,VSS score,and 12-PSS score in Group C were significantly lower than those in Group B and Group A,with statistical significance(P＜0.01);The incidence of adverse reac-tions in Group C was lower than that in Group A and Group B,but the difference was not statistically significant(P＞0.05).Conclusion The combination of nucleus pulposus dissection and bleomycin injection for the treatment of ear scar tissue is more effective in reducing TGF-β1 and EGF levels,improving scar conditions,and has higher safety compared to the combination of compound betamethasone injection.