The role of macrophage polarization in wound healing and its prospective applications
ZHANG Jiarui
PENG Yixuan
XIAO Zhibo
Abstract：Wound repair is a complex and tightly regulated physiological process that significantly impacts the quality of a patient's recovery.The sequential phases of inflammation,proliferation,and remodeling within the healing process are pivotal in determining the fi-nal outcome of wound healing.Macrophages,as key participants in the inflammatory response,can polarize into two distinct phenotypes,M1 and M2,which are associated with pro-inflammatory and anti-inflammatory roles,respectively.This polarization allows for a dynamic regu-lation of the healing process.This review aims to investigate the role of macrophage polarization in the wound healing process and its poten-tial therapeutic applications for enhancing healing by synthesizing the latest research findings from the literature.
Keywords：MacrophagesPolarizationWound healing
Publication Date：2025-03-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 189-192 )