Efficacy observation of Q-switched 1064 nm laser combined with hydrographic injection and microneedling for the treatment of melasma

ZHU Hongyan; CHEN Xing; SHI Lei

doi:10.3969/j.issn.1673-7040.2025.03.013

Abstract：Objective To observe the clinical efficacy of Q-switched 1064 nm laser with hydro-light injection and microneedle in the treatment of melasma.Methods From September 2023 to September 2024,a total of 104 patients who were admitted from Depare-ment of Dermatology,Suzhou Hospital Affiliated to Nanjing Medical University were selected and randomly divided into a control group(36 cases),a observation group 1(34 cases)and a observation group 2(34 cases).The efficacy was evaluated by melasma area and severity index(MASI),skin detector,and patient satisfaction before,after and six months after treatment.The average recovery time and the inci-dence of complications after treatment were also recorded.Results After the last treatment,the MASI scores of the three groups were low-er than before treatment.The total effective rate of the observation group was 67.65％(46/68),which was higher than that of the control group 44.44％(16/36).The effective rate of the observation group 2 was 73.53％(25/34),which was higher than that of the observation group 1 61.76％(21/34),the difference is statistically significant(P＜0.05).The average recovery time of observation group 2(7.27±1.84)d was significantly shorter than that of observation group 1(9.55±2.15)d and the control group(10.82±2.56)d,the difference is statistically significant(P＜0.05).The incidence of complications after treatment was significantly different among the three groups(P＜0.05).Conclu-sion Compared with the photoelectric therapy group alone,the photoelectric combined with water light and microneedle therapy group has a significant effect in treating chloasma,and the recovery time is shorter and the safety is higher.