The application of adipose-derived stem cells exosomes in suppressing keloid formation
HUANGFU Mingfang
CHEN Minliang
Abstract：Keloids are fibrotic diseases caused by dysregulation of the wound healing process,with clinical manifestations as site of injury,occasional pain,itching and other discomfort and usually is self-unlimited.In recent years,adipose-derived stem cells exosomes(ADSCs-exo)have been widely used in plastic and reconstructive surgeries.A large number of studies have shown to inhibit KFs formation in a paracrine way.However,the etiology and pathogenesis of keloid are still not clear,the mechanism underlying keloids and the thera-peutic target of ADSCs remains unknown.This article reviews the research progress on signaling pathways of keloids and the application of ADSCs-exo in keloids.
Keywords：KeloidSignal pathwayAdipose-derived stem cells ADSCsExosomes
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 109-114 )