Gut microbiota and the risk of facial skin aging:a Mendelian randomization analysis
RONG Jian
FAN Xin
WANG Xin
LI Yaoyao
XIE Dong
SONG Mei
Abstract：Objective A Mendelian randomization approach was used to assess the potential causal relationship between gas-trointestinal microorganisms and the risk of facial ageing.Methods From December 2023 to March 2024,Genome-wide association analysis(GWAS)meta-data of 196 bacterial taxa(9 phylums,20 orders,16 classes,35 families,and 131 genera)using the MiBioGen con-sortium of intestinal flora were included in the analysis.Inverse variance weighting,MR-Egger regression,and weighted median method were used to investigate the causal relationship between gut flora and facial aging.Sensitivity analysis was used to test the reliability of the results of Mendelian randomization analysis.Results For facial skin aging,IVW initially identified 10 taxa with potential causal effects on facial skin aging.Genus Parasutterella is negatively associated with facial skin aging.Phylum.Verrucomicrobia,Family.Lactobacillaceae,Genus.Butyricimonas,Genus.Eggerthella,Genus.Family ⅩⅢ UCG001,Genus.Lactobacillus,Genus.Parabacteroides,Genus.Phasco-larctobacterium.Genus Ruminococcaceae UCG005 are positively associated with facial skin aging.Conclusion For facial skin aging,IVW initially identified 10 taxa with potential causal effects on facial skin aging.
Keywords：Mendelian randomizationGut microbiotaFacial agingCausal relationshipSkin
Publication Date：2025-02-14
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 90-95 )