Observation on the therapeutic effect of tranexamic acid combined with superpulsed CO2 lattice laser in improving skin pig-mentation

YE Huan; CAI Xiang

doi:10.3969/j.issn.1673-7040.2025.02.003

Abstract：Objective To observe the effect of tranexamic acid combined with superpulsed CO2 lattice laser in treating facial post-burn pigmentation.Methods From March 2021 to March 2022,110 patients with facial post-burn pigmentation were collected and randomly separated into an observation group and a reference group using the number table method,with 55 cases in each group,the refer-ence group was treated with superpulsed CO2 lattice laser,while the observation group was treated with tranexamic acid combined with su-perpulsed CO2 lattice laser.Both groups were treated once a month,a total of 3 times as a course of treatment.The clinical efficacy,satis-faction,facial pigmentation area,depth of pigment color,and adverse reaction of the two groups were compared.Results Six months after the end of treatment,the total clinical effective rate(92.73％)and satisfaction rate(87.27％)of the observation group were higher than those of the reference group(74.55％and 69.09％),P＜0.05.After 2 times of treatment and at the end of treatment,the facial pigmentation area scores of both groups decreased,and at the same time point,the observation group(1.71±0.25)points and(1.05±0.16)points was lower than the reference group(1.91±0.28)points and(1.18±0.19)points(P＜0.05).After 2 times of treatment and at the end of treatment,the severity scores of pigmentation in both groups decreased,and at the same time point,the observation group(2.51±0.57)points and(0.99±0.22)points was lower than the reference group(2.94±0.63)points and(1.31±0.24)points(P＜0.05).6 months after the end of treatment,the recurrence rate in the observation group(3.64％)was lower than that in the reference group(14.55％),P=0.036.Conclusion Tranateic acid combined with superpulse CO2 dot matrix laser can effectively improve the pigmentation symptoms of patients after facial burn,and the clinical effect is good,the adverse reactions are slight,and the patient satisfaction is high,which is worthy of clinical promotion.