Analysis of the correlation between ZMYND8 and the occurrence,prognosis and immune infiltration of malignant melanoma
RONG Jian
CHANG Peng
WANG Xin
LI Yaoyao
LIAN Juan
SONG Mei
Abstract：Objective To use online databases and bioinformatics methods to analyze the expression level of ZMYND8 in malig-nant melanoma(MM)and its association with MM development,prognosis,and immune cell infiltration.Methods The GEPIA online database(TCGA data)was used to analyze the expression of ZMYND8 in a variety of normal tissues compared with the cancer tissues,and the GEO data was further used to confirm the distinctions in the expression of ZMYND8 in MM;the UALCAN database analyzed the corre-lation between ZMYND8 and the prognosis of MM patients;and The Human Protein Atlas database was used to to analyze the immunohis-tochemical expression of ZMYND8 in MM tissues;String database to establish the protein interactions network of ZMYND8 co-expressed genes;and TMER database to analyze the association between ZMYND8 expression and immune cells infiltrating.Results In MM tissues,the expression level of ZMYND8 was higher than that in normal tissues(P＜0.01);the high transcription level of ZMYND8 was highly cor-related with gender,age,obesity status,lymphatic metastasis,and cancer staging stage(P＜0.05);and the expression level of ZMYND8 mRNA was correlated with the prognosis of MM and immune cell infiltration(P＜0.05).Conclusion ZMYND8 is highly expressed in MM,and its correlation with MM development,prognosis,and immune cells infiltration may serve as a potential marker for the diagnosis,prognosis,and drug treatment of MM.
Keywords：Malignant melanomaZMYND8GenePrognosisImmunization
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 726-729,后插3 )