Research progress of pathological scar in animal models
SHI Shujie
XUE Chunyu
Abstract：Pathological scar is the result of an excessive tissue response due to hyperplasia of dermis and overproduction of collagen following skin injury,including hypertrophic scars and keloid.The high prevalence of pathological scar and its adverse effects on patients'quality of life,physical condition and psychological well-being make it particularly urgent to study its etiology,epidemiolo-gy,histology,pathophysiology,and advances in preventive and therapeutic approaches.Although cell or tissue cultures are suitable for studying the mechanisms of sacr pathophysiology,it is necessary to use animal models to assess the efficacy and safety of new thera-pies.Animal models of hypertrophic scars can be induced by burns,injected drugs and surgical incisions,etc.Animal keloid models are currently limited to those obtained by transplantation of human keloids or specific cells,etc,thus making hypertrophic scars a cur-rent focus of animal model research.
Keywords：Pathological scarHypertrophic scarKeloidAnimal model
Publication Date：2024-11-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 692-696 )