Efficacy of delicate palsed light combined with variable inversion in the treatment of rosacea's refractory erythema
QIU Baiyi
CAI Xiang
SUN Bangmei
QIN Zongbi
LIU Qilin
Abstract：Objective To investigate the efficacy of delicate palsed light combined with variable inversion in the treatment of rosacea's refractory erythema.Methods From May 2020 to May 2022,88 patients with rosacea-refractory erythema who were treated in the outpatient clinic of our hospital were selected,and all patients were assigned to the delicate palsed light group(n=44)and joint group(n=44)according to the random number table method,and the delicate palsed light group was treated with delicate palsed light,and the joint group was combined with variable prescription upside down basis on the delicate palsed light group;the patients'quality of life was scored with Dermatology Life Quality Index(DLQI);the efficacy,clinical symptom score,score barrier function index,clinical symptom re-lief time,DLQI score,and occurrence of adverse conditions were compared between the two groups.Results The total effective rate of treatment in the combination group was significantly better than that of the delicate palsed light group(P＜0.05);the telangiectasias,burn-ing and erythema scores in the combined group and the delicate palsed light group were significantly lower(P＜0.05)after treatment,and the telangiectasias[(0.49±0.13)points],burning[(0.73±0.18)points]and erythema points[(0.36±0.11)points]in the combined group were significantly lower than those in the delicate palsed light group(0.93±0.28),(0.84±0.20)and(0.84±0.23)points](P＜0.05),telangiectasia[(17.24±4.17)d],skin flushing[(16.25±3.87)d],skin sensitivity[(17.49±4.33)d],and erythema relief time[(17.21±4.52)d]were significantly lower than those in the delicate palsed light group[(25.46±5.83)d,(23.72±5.39)d,(26.82±6.24)d,(28.16±6.37)d](P＜0.05).The DLQI scores of the combined group and the delicate palsed light group were significantly reduced after treatment(P＜0.05),and the DLQI score[(6.35±1.62)points]of the combined group after treatment was significantly lower than that of the delicate palsed light group[(11.42±2.13)points](P＜0.05),and the skin erythema index and percutaneous water loss in the combined group and the delicate palsed light group were significantly reduced after treatment.The water content of the stratum corneum was significantly increased(P＜0.05),the skin erythema index(330.56±27.34)and percutaneous water loss[(16.39±4.19)g/(h·m-2)]in the combined group were signifi-cantly lower than those in the delicate palsed light group(355.28±26.27),[(19.37±4.68)g/(h rr-2)],and the water content of the stratum corneum[(47.69±7.59)％]was significantly higher than that in the delicate palsed light group[(36.87±6.29)％](P＜0.05).the treatment methods and treatment effects of the combined group were significantly better than those in the delicate palsed light group(P＜0.05),and the incidence of adverse reactions in the combination group(13.64％,6/44)was significantly lower than that in the delicate palsed light group(34.09％,15/44)(x2=5.066,P=0.024).Conclusion Delicate palsed light combined with variable square reversal can effectively im-prove the symptom score and quality of life of patients with rosacea-refractory erythema,shorten the symptom relief time,and have signifi-cant effects.
Keywords：Refractory erythema of rosaceaDelicate palsed light(DPL)Diandao powderCurative effect
Publication Date：2024-06-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 344-348,352 )