Evaluation of the effect of microdermal granulation autologous wound transplantation on diabetic foot ulcer

LAI Haijing; LIU Jiaming; SU Jing; ZHOU Xiaoqian; WANG Peng; JIANG Liyuan; WANG Yu; MA Xinrui; XIAO Houan

doi:10.3969/j.issn.1673-7040.2023.12.008

Abstract：Objective To evaluate the effect of microdermal granulation autologous wound transplantation in the treatment of dia-betic foot ulcer.Methods From June 2021 to December 2021,46 patients with Wagner3-4 diabetic ulcer were admitted to the Depart-ment of Burn and Plastic Surgery in the Ninth Hospital of Xi'an.According to the treatment method,patients were divided into two groups,23 cases each group.The control group was treated with traditional microskin graft,and the intervention group was treated with au-togenous microskin granulation wound graft.The wound tissue was collected before surgery and 2 and 4 weeks after surgery.The concen-tration of advanced glycation endproducts(AGEs)and receptor of advanced glycation endproducts(RAGE)in tissue homogenates was de-termined by ELISA method,and the wounds treatment effect were compared.Results Before treatment,there was no statistical difference in the general situation,AGEs concentration,RAGE concentration and wound condition between the two groups(P>0.05),which was com-parable.The wound area of 2 weeks and 4 weeks after the treatment in the control group and the intervention group was smaller than that before the treatment respectively,but the reduction was more significant in the intervention group(P<0.05).The concentrations of AGEs and RAGE in the wound tissue of the two groups were lower than before at all treatment nodes,and the intervention group was better than the control group(P<0.05).The effective rate of the intervention group was 95.7%.The effective rate of control group was 69.6%,and the effect of intervention group was more significant(P<0.05).Conclusion Autologous microgranular skin granulation implantation can im-prove and promote the repair of diabetic foot ulcer wounds,significantly reduce the expression of AGEs and RAGE,which provide theoreti-cal basis for clinical and drug treatment of diabetic foot.