Experimental study on improving biocompatibility of Silicone Rubber by multicarboxylsilsesquioxane
SHI Xiao-hua
ZHOU Xin
CHEN Yao
DU Yi-che
FAN Dong-li
Abstract：Objective To prepare multicarboxylsilsesquioxane (POSS-COOHx) hybrid silicone rubber and study its biocompatihility.Methods (1)Through halogenation and oxidation reduction reaction,eight phenyl silsesquioxane was converted to muhicarboxyl eight phenyl silsesquioxane,and was then mixed with liquid two-component silicone rubber,the mixture was cured at room temperature and multicarboxylsilsesquioxane (POSS-COOHx) hybrid silicone rubber was acquired.(2)Cell compatibility was examined by CCK-8 and cell skeleton staining.In vivo implantation test and HE staining were used to detect the biocompatibility of muhicarboxylsilsesquioxane (POSS-COOHx) hybrid silicone rubber.Results (1)Multicarboxylsilsesquioxane (POSS-COOHx) hybrid silicone rubber was successfully prepared;(2)The biocompatibility of multicarboxylsilsesquioxane (POSS-COOHx) hybrid silicone rubber improved more significantly than ordinary silicone rubber.Conclusion Cage-type silsesquioxane can be used as a good molecular platform to introduce hydrophilic groups to change the surface properties of biomaterials and to improve the biocompatibility of biomaterials.
Keywords：MulticarboxylMulti carboxyl cage-type silsesquioxaneSilicone rubberBiocompatibility
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 224-227,后插4 )