Inhibition of guinea pig melanin induced by Estrogen and UV under the therapy of Q-switched ruby laser combined with tranexamic acid for external use
LI Qian
CAO Mo
Abstract：Objective To verify the clinical efficacy of Q-switched ruby laser combined with tranexamic acid in the treatment of pigmentation.Methods From 2015 to 2016 guinea pig pigmentation experimental models induced by estrogen and UVB were established,and were divided into four groups:(A) the untreated group,(B) the tranexamic acid for external use alone group,(C) the Q-switched ruby laser alone group and (D) the Q-switched ruby laser combined with tranexamic acid for external use.All groups received treatment for 1 month.The epidermal pigmentation and quantity and melanocytes of pigment particles expressing change were observed before and after treatment at 2 and 4 weeks by photo visual assessment,melanocytic staining (Imokawa method),and melanin granules staining (Masson-Fontana method).Results Using the percentage of the area of melanin granules and the number of cells in each group,experimental results showed that low-energy density dot matrix QSRL was able to reduce the number of melanocytes,make the melanin particles smaller,and was effective in the treatment of pigmentation (P ＜ 0.05).The tranexamic acid injection for external use alone group was not significantly different from the untreated group,with no significant loss of pigment (P ＞ 0.05).No statistical significance differences existed between the combination therapy and dot matrix laser treatment alone (P ＞ 0.05).Conclusion Q-switched ruby laser has obvious efficacy in the treatment of chloasma.The study has shown that tranexamic acid as an external medicine,whether on its own or combined with lattice QSRL,does not play a significant role.
Keywords：ChloasmaUltraviolet raysQ-switched ruby laserTranexamic acidEfficacy of treatment
Publication Date：2018-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 141-144,152 )