Analysis of the correlation between the HIF-1α expression and inflammatory factors in different types of scars
ZHANG Ming-zi
WANG Chen-yu
GUAN En-ling
CHEN Zhi-xiong
LONG Fei
YU Nan-ze
SI Lou-bin
HUANG Jiu-zuo
LONG Xiao
WANG Xiao-jun
Abstract：Objective To study the expression level of HIF-1 α,IL-6,IL-8 and TGF-β in normal skin,scar and keloid tissue,and the correlation between the HIF-1 α expression and other inflammatory factors.Methods From Jan.to Dec.2016,18 patients with keloids (6 scar-free patients,6 scar patients,and 6 keloid patients) were selected from the plastic surgery department and randomly divided into 3 groups:the normal skin group (group A),the scar group (group B) and the keloid group (group C).There were 6 cases in each group.The morphological changes,inflammatory infiltration and the expression level of HIF-1 α,IL-6,IL-8 and TGF-β in the various scar tissues were analyzed through H&E staining,immunohistochemical staining,and Western blot.The correlation between HIF-1 α and other inflammatory factors was also measured and analyzed.Results There was a lot of inflammatory cell infiltration in the keloid tissue.The expression level of HIF-1 α,IL-6,IL-8,and TGF-β in group C was significantly higher than that in the other groups.In the correlation analysis,there were positive correlations between HIF-1 α expression and other inflammatory factors (IL-6,IL-8,TGF-β).Conclusion Hypoxia microenvironment is the basic environment of keloids.The degree of hypoxia might be related to the inflammatory level.
Keywords：ScarKeloidHypoxia inducible factor-1αInflammatory factors
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 324-327 )