Establishment of skin and soft tissue expansion at parietal region in a rabbit model
WANG Fei
SU Ying-jun
YU Zhou
MA Xian-jie
GUO Shu-zhong
Abstract：Objective To establish a rabbit model of skin and soft tissue expansion in the parietal region,to research histological changes and expansion and contraction properties of the expanded skin,to verify the efficacy of the expansion,and to provide a stable animal model for the basic research of skin and soft tissue expansion.Methods Twenty New Zealand white rabbits were divided into 2 groups,10 rabbits in each group and weighing 3 kg each.In group A,a skin and soft tissue expander of 80 ml was subcutaneously implanted in the parietal region of each rabbit.Normal saline was injected into the expander once per day postoperative until the internal pressure reached 30 mmHg.This process took a total of 20 days.Taking B group as a control group,the same expander was subcutaneously implanted but without expansions.The proportion of expansion and contraction of the skin was measured and calculated.The skin samples in the expanded center region of the two groups were adopted and HE stain was performed.Changes in skin structure were observed under microscope.Results The expanded region was obvious in group A,the expansion rate was (239.66-± 41.92)％ and the retraction rate was (31.63 ± 3.62)％.Compared with group B,the epidermal layer of the expanded region was significantly thickened in group A,as observed through HE stain.Conclusion Skin and soft tissue expansion in the parietal region of rabbits can provide a satisfactory model for skin expansion research.
Keywords：Skin and soft tissue expansionParietal regionAnimal modelRabbit
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 302-305 )