Effect of propranolol on the expression of matrix metalloproteinase in the urine of infantile hemangioma patients
GAO Jian
XU Xiao
WANG Hong-yi
ZHANG Rong-ming
Abstract：Objective To explore the effect and mechanism of propranolol by analyzing the level of MMP-9 and MMP-2 in the urine of infantile hemangioma (IH) patients.Methods Oral propranolol was administered in 18 IH patients in the treatment group.The dose was 1.0～1.5 mg/kg once per day for 4 to 8 months.The untreated IH patients served as the control group.The level of MMP-2 and MMP-9 in the urine of both groups was compared and analyzed before treatment as well as 1 month and 3 months after treatment.Results (1) The growth of hemangiomata was inhibited in the treatment group after oral propranolol.Inhibition of gTowth mainly manifested in significantly reduced tumor volume,fading of color on the tumor surface,and significantly decreased tension.(2) The~ is no statistical difference in the level of expression of MMP-2 and MMP-9 in the urine between the two groups before treatment (P＞0.05).One month and 3 months after treatment,the level of expression of MMP-2 and MMP-9 in the urine between the two groups shows significant difference (P＜0.05).Conclusion Propranolol may exert an effect by down grading the level of MMP-9 and MMP-2 in the treatment of IH.It is one of the mechanisms of propranolol in the treatment of IH.
Keywords：Infantile HemangiomaMatrix Metalloproteinases (MMPs)PropranololExpression levelMechanisms
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 299-301 )