Construction of rat exposed bone wound repair model by artificial dermis composite tissue flap
WANG Yu-chong
LYU Chuan
ZHU Ji
DAI Hai-ying
ZHAO Hui
FAN Yong-jie
SUN Meng-yan
WU Kai
XUE Chun-yu
Abstract：Objective To construct a rat exposed bone wound repair modelby artificial dermis composite flap,andto explore the difference between the effect of artificial dermis direct repair and skin graft repair,and to provide a stable animal model for the studyof the effect of composite tissue flap repair.Methods The SD rats were randomly divided into forr groups:A,B,C and D (n =15).Group A was treated with artificial dermis composite tissue flap to repair the wound.Group B was treated with subcutaneous implantation of artificial dermis to repair the wound.Group C was treated with artificial dennis implantation under the fascia for direct repair of the wound.Group D was treated byskin grafting.The condition of the repair was observed on dlays 7,14,21,and 28.Results Group A wounds were completely healedby 28 daypost-operative.Wounds in the remaining groups did not achieve complete healing.Conclusion The application of artificial dermis composite tissue flap is a feasible method in the repair of rat exposed bone wounds.
Keywords：Composite tissue flapArtificial dermisWoundRepairAnimal model
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 222-225 )