Effect of TSG-6 on MMP-2 and TIMP-2 expression and scar repairing in cicatrization
WEN Ke
YU Dong-mei
LIU Yi-lun
Abstract：Objective To investigate the influence of TSG-6 on MMP-2 and TIMP-2 expression and scar repairing in cicatrization in the model of rabbit ear scar.Methods A rabbit ear scar model was established according to the Morris method.The left ear was selected as the experimental group and injected with TSG-6,and the right ear,as the control group,was injected with the same dose of sterile normal saline.The condition of scar hyperplasia was evaluated by scar index and Ⅰ and Ⅲ collagen expression.The expression of MMP-2 and TIMP-2 gene was also tested.Results The scar index and Ⅰ and Ⅲ collagen content in the experimental group were less than that in the control group.MMP-2 expressed relatively higher and TIMP-2 expressed lower.The difference was statistically significant (P＜0.05).Conclusion Scar hyperplasia can be inhibited by TSG-6.The mechanism increased MMP-2 expression in cicatricial tissue.
Keywords：ScarTSF-6Matrix metalloproteinase-2Matrix metallo-proteinase inhibitor
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 170-172 )