Prevention of hypertrophic scars by 5 -aminolaevulinic acid-mediated photodynamic therapy in a rabbit ear model
Abstract：Objective To investigate the effects of 5 - aminolaevulinic acid- mediated photodynamic therapy (ALA-PDT)on hypertrophic scars in a rabbit ear model.Methods The acute model of dermal hypertrophic scar was established in the rabbit ears.Totally 108 scar wounds were randomly divided into 4 groups:the blank control group,the laser treatment group,the ALA injection group and the ALA-PDT group.In the ALA-PDT group,5 h after intra-dermal injection of ALA,the scars were irradia-ted at 635 nm wavelength, 100 mW/cm2 for 20 min.Three weeks after treatment,the scars thickness and erythema index were measured,and the specimens were harvested for histological analysis by HE and Masson staining.Results The thickness,erythema index and the scar elevation index were signifi-cantly decreased while the number of apoptosis of fibroblasts increased in the ALA-PDT group com-pared to the other groups.Well organized collagen fiber was observed in the ALA-PDT group by Mas-son staining.Conclusion ALA-PDT could prevent the growth of hypertrophic scars in rabbit ears.
Keywords：5-aminolaevulinic acidPhotodynamic therapyHypertrophic scar
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 700-704 )