Observation on biologic characterization of polyacrylamide gel and silicone gel infused into mammary gland of domestic musk swine

ZHOU Zhi; LU Kai-hua

doi:10.3969/j.issn.1673-7040.2001.02.005

Abstract：Objective　To explore and compare the biological reaction of polyacrylamide gel and silicone gel injected under breast tissue of domestic pig. To gain the theoretical basis for the clinical application. Methods　The capsule of implants were observed with pathological technique, and the filling materials were determined with high-performance liquid chromatography. Results　Fibrous tissue surrounding the filling materials was observed 2 weeks after the injection of polyacrylamide gel and silicone gel. 1 months after the injection, The capsular of polyacrylamide gel is much thinner than that of silicone gel, and 4 months after the injection it has tendency to become thinner gradually, and in the end it steadily remains 3～5 layers of fibroblast. In regard of acute and chronic inflammatory reaction and foreign body stimulating reaction, the result of the group with polyacrylamide gel is also better than that with silicone gel. The C type domestic polyacrylamide gel injected into the pig remains 78.33 percent of the original volume after 1 year, while 78.95 percent after 4 months. In the various periods within 1 year, with liquid chromatography at 254 nm wavelength and 0.5μg/ml, we can’t detect acrylamide monomer separated from polyacrylamide gel in the tissue. In the gross dissection, we find that “honeycomb structure” was developed in breast tissue. Conclusion　So we believe polyacrylamide gel is stable at least within 1 year in physiological condition.