Effects of PGE2 on type Ⅰ and Ⅲ procollagen mRNA expression in scar-derived fibroblasts
WANG Yong
HE Qing-lian
LIN Zi-hao
Abstract：Objective The mechanisms of inhibitory effects of PGE2 on collagen synthesis in scar derived fibroblasts was investigated.Methods Fibroblasts was isolated from fresh hypertrophic tissue and cultured, exposed to PGE2. The concentration of type Ⅰ and Ⅲ procollagen mRNA expression in scar-fibroblasts were assayed by Dot blot hybridization. Results PGE2 significantly reduced type Ⅰ and Ⅲ procollagen mRNA expression in scar-fibroblasts. Conclusion PGE2 inhibits collagen synthesis of scar-fibroblasts at transcriptional level.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 35-37 )