Analysis on level of 25-hydroxyvitamin D in children in a certain region

Zhang Hongjing; Guo Jinjie; Yang Rui

doi:10.3969/j.issn.1674-7151.2025.04.018

Abstract：Objective To analyze the level of 25-hydroxyvitamin D[25(OH)D]in children in Chifeng area,Inner Mongolia Autonomous Region,explore its correlation with serum calcium(Ca),phosphorus(P)and alkaline phosphatase(ALP),and provide a reference for the nutritional and health status of children in this area.Methods The biochemical index test results of 806 children aged 0-13 who underwent physical examination at Chifeng Songshan Hospital from June to December 2024 were collected,including serum 25(OH)D,Ca,P and ALP.According to age,the children were divided into 1-3 years old group(145 cases),4-6 years old group(219 cases)and 7-13 years old group(442 cases).They were also divided into 25(OH)D deficiency group(136 cases),25(OH)D insufficiency group(200 cases)and 25(OH)D sufficiency group(470 cases)based on 25(OH)D levels.The baseline data from each group and factors affecting 25(OH)D in children were analyzed,and the correlations between 25(OH)D levels and serum Ca,P and ALP levels were investigated using Pearson correlation analysis.Results Among boys of 1-3 years old group,4-6 years old group and 7-13 years old group,the proportions of 25(OH)D deficiency were 3.5%,10.5%and 23.1%,respectively,while the proportions of 25(OH)D sufficiency were 74.7%,61.7%and 52.7%,respectively.Among girls of 1-3 years old group,4-6 years old group and 7-13 years old group,the proportions of 25(OH)D deficiency were 3.4%,15.1%and 24.2%,respectively,the proportions of 25(OH)D insufficiency were 12.1%,22.1%and 30.3%,respectively,the proportions of 25(OH)D sufficiency were 84.5%,62.8%and 45.5%,respectively,and the differences were statistically significant(all P<0.05).Compared with children in 1-3 years old group,the 25(OH)D levels in children of 4-6 years old group and 7-13 years old group decreased significantly(μg/L:34.94±12.83 vs.24.93±7.51,21.94±6.78,both P<0.001),and the level of 25(OH)D in 7-13 years old group was significantly lower than that in 4-6 years old group(P<0.05).Compared with 1-3 years old group,the serum levels of Ca in 4-6 years old group and 7-13 years old group were significantly reduced(mmol/L:2.53±0.12 vs.2.45±1.04,2.45±0.12,both P<0.001).The serum levels of Ca in 25(OH)D sufficiency group were significantly higher than those in 25(OH)D deficiency group and 25(OH)D insufficiency group(mmol/L:2.53±0.21 vs.2.25±0.16,2.10±0.22,both P<0.05),while the serum levels of ALP were significantly lower than those in 25(OH)D deficiency group and 25(OH)D insufficiency group(mmol/L:207.00±63.89 vs.225.30±91.23,218.00±65.62,both P<0.05).The Pearson correlation analysis results showed that serum 25(OH)D was positively correlated with Ca,and negatively correlated with serum ALP(r values were 0.61 and-0.49,P values were 0.031 and 0.028,respectively).Conclusion Children in different age groups in Chifeng area have varying degrees of vitamin D deficiency,which is related to the season and serum Ca and ALP.